Background. The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty\nliver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study.\nMethods. Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum\ninsulin, and liver ultrasound. Results. Forty-four children (58.6%) were found to have MS. Insulin resistance was present in\n78 (62.4%) children. Patients with MS were more likely to have NAFLD (P < 0 001). Children with NAFLD had significantly\nhigher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to\npatients with normal livers (P < 0 001). Insulin resistance was significantly higher in children with NAFLD (P < 0 001). Obese\nchildren presenting with MS were 3.01 (2.87ââ?¬â??3.57, P < 0 002) times more likely to develop NAFLD compared to those without\nmetabolic syndrome after adjustment of cofounders. Conclusions. Obese children with MS have a higher risk of developing\nNAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues\nlater on.
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